AustralieFrV1, Main, Exploration, bibRecord, 005238

The PCSK9 decade

Identifieur interne : 005238 ( Main/Exploration ); précédent : 005237; suivant : 005239

The PCSK9 decade

Auteurs : Gilles Lambert [France, Australie] ; Barbara Sjouke [Pays-Bas] ; Benjamin Choque [Australie] ; John J. P. Kastelein [Pays-Bas] ; G. Kees Hovingh [Pays-Bas]

Source :

Journal of Lipid Research [ 0022-2275 ] ; 2012.

RBID : PMC:3494258

Abstract

PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor. In recent years, both in vitro and in vivo studies have greatly supplemented our understanding of the (patho)physiological role of PCSK9 in human biology. In the current review, we summarize studies published or in print before May 2012 concerning the physiological role of PCSK9 in cholesterol metabolism. Moreover, we briefly describe the clinical phenotypes encountered in carriers of mutations in the gene encoding PCSK9. As PCSK9 has emerged as a novel target for LDL-C lowering therapy, methods to inhibit PCSK9 will also be reviewed. Initial data from investigations of PCSK9 inhibition in humans are promising and indicate that PCSK9 inhibition may be a viable new therapeutic option for the treatment of dyslipidemia and associated cardiovascular diseases.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494258

DOI: 10.1194/jlr.R026658
PubMed: 22811413
PubMed Central: 3494258

Affiliations:

Australie, France, Pays-Bas

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The PCSK9 decade

The PCSK9 decade

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Abstract

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